NCI, cooperative groups gear up for changes in clinical trials system

Cooperative groups say NCI trials funding inadequate; some turn to industry.

To calculate total funding for a given trial, investigators multiply the number of patients by the $2,000 reimbursement. The resulting value represents the bulk of what NCI will pay for a trial, including long-term follow-up. Faced with a stagnant budget, NCI hasn't raised the reimbursement rate for 7 years, while median costs per subject have reached $6,000 and beyond, according to the Lewin G...

The role of cooperative groups in cancer clinical trials.

Clinical trials referral resource. Current clinical trials of the Cancer Trials Support Unit (CTSU), an NCI pilot program.

The Cancer Trials Support Unit (CTSU) is a pilot program sponsored by the National Cancer Institute (NCI). The CTSU has two primary functions. It centralizes regulatory support for all adult Cooperative Group trials (phases IIII), thereby reducing duplication among Group members regarding credentialing, compliance with federal regulations, and institutional review board (IRB) activities. It als...

Cooperative Clinical Trials in Cancer – the need for increased capacity

Acknowledgements Sincere thanks are offered to the many people who have given up their time to contribute to this report by participation in interviews, providing comments on the drafts, participation in the workshop and in assisting in many other ways. The contributions of so many busy people has been of inestimable value and is greatly appreciated. The fact that it has not been possible to re...

The Cooperative Landscape of Multinational Clinical Trials

The scale and nature of cooperative efforts spanning geopolitical borders in clinical research have not been elucidated to date. In a cross-sectional study of 110,428 interventional trials registered in Clinicaltrials.gov, we characterized the evolution, trial demographics, and network properties of multinational clinical research. We reveal that the relative growth of international collaborati...